منابع مشابه
Distinct signaling pathways control Toxoplasma egress and host-cell invasion
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متن کاملFunctional Analysis of Rhomboid Proteases during Toxoplasma Invasion
Host cell invasion by Toxoplasma gondii and other apicomplexan parasites requires transmembrane adhesins that mediate binding to receptors on the substrate and host cell to facilitate motility and invasion. Rhomboid proteases (ROMs) are thought to cleave adhesins within their transmembrane segments, thus allowing the parasite to disengage from receptors and completely enter the host cell. To ex...
متن کاملToxoplasma Actin Is Required for Efficient Host Cell Invasion
UNLABELLED Apicomplexan parasites actively invade host cells using a mechanism predicted to be powered by a parasite actin-dependent myosin motor. In the model apicomplexan Toxoplasma gondii, inducible knockout of the actin gene, ACT1, was recently demonstrated to limit but not completely abolish invasion. This observation has led to the provocative suggestion that T. gondii possesses alternati...
متن کامل4-Bromophenacyl Bromide Specifically Inhibits Rhoptry Secretion during Toxoplasma Invasion
Toxoplasma gondii is a eukaryotic parasite of the phylum Apicomplexa that is able to infect a wide variety of host cells. During its active invasion process it secretes proteins from discrete secretory organelles: the micronemes, rhoptries and dense granules. Although a number of rhoptry proteins have been shown to be involved in important interactions with the host cell, very little is known a...
متن کاملPlasticity and Redundancy in Proteins Important for Toxoplasma Invasion
Phenotypic plasticity encompasses the versatile abilities of an organism to modify its phenotype according to changes in the environment. Such adaptations, in response to a decrease of fitness, are commonly exploited by microorganisms and plants that cannot easily escape their environment and, hence, are at risk of extinction. Functional redundancy and plasticity is therefore anticipated for ob...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.339.6117.251-c